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Many people seek alternatives to melatonin when looking for ways to manage sleep issues. While melatonin supplements are popular, they are not suitable for long-term use as they can create imbalance in your brain. Fortunately, these melatonin alternatives are safe and easy to use to get the rest that you need.

Top 10 Alternatives to Melatonin Supplements

 

Top melatonin-free options for sleep:

 

  1. MDsleep + Hemp Sleep AId
    This oil, extracted from Nigella sativa, encourages relaxation and supports restful nights. Its antioxidant effects also contribute to overall well-being and may help lower stress-related issues that disrupt sleep.
  2. MDsleep Botanical Blend
    A well-known adaptogen, ashwagandha assists the body in adapting to stressful situations. It can help quiet the mind at bedtime, encourage a full night’s rest, and enhance how efficiently people spend their time in bed sleeping.
  3. Lemon Balm
    With a calming influence, lemon balm promotes peace of mind and supports the nervous system. It is a traditional option for helping manage stress and maintain a steady sleep pattern.   
  4. Valerian Root
    Valerian root has long been chosen for its gentle sedative-like abilities and valerian has been studied vs melatonin.
  5. GABA (Gamma-Aminobutyric Acid)
    Supplementing with GABA may establish a sense of calm by promoting relaxation in the brain and reducing pre-bedtime tension.
  6. CBN
    CBN (cannabinol) has shown potential as a sleep aid by reducing nighttime awakenings and sleep disturbances, although it may not significantly help people fall asleep faster or improve overall sleep quality. Early studies suggest CBN can increase sleep duration and has sedative properties, but more high-quality research is needed to confirm its effectiveness for insomnia.
  7. CBG CBG (cannabigerol) is being studies to see how much it can help to improve sleep quality and reduce stress. Preliminary studies suggest CBG may have unique pharmacological effects that could support sleep and more robust clinical trials are already underway.
  8. Magnesium
    Known for its relaxing qualities, magnesium plays a crucial role in supporting normal nerve function and helping muscles relax, which can promote an easier transition into sleep.
  9. Lavender
    Often used in aromatherapy or oral supplements, lavender contributes to nighttime calm and can foster higher quality rest.
  10. Cannabidiol (CBD)
    CBD offers a possible option for relaxing the body and mind, helping some sleepers settle down more easily.

MDsleep + Hemp Sleep Supplement

 

MDsleep + Hemp Sleep Supplement features a thoughtful mix of ingredients that target various aspects of relaxation and sleep quality. The supplement includes amino acids such as L-tryptophan and glycine, both of which play roles in natural sleep regulation. L-tryptophan is involved in the body’s own neurotransmitter pathways that relate to sleep, while glycine balances calming signals in the brain.

 

MDsleep + Hemp Sleep Supplement Ingredients

MDsleep + Hemp Sleep Supplement Ingredients

Key Points:

  • Contains a non-intoxicating form of hemp alongside well-established sleep-supporting ingredients.
  • Melatonin free to avoid rebound insomnia.
  • Combines amino acids, minerals, and botanical extracts for a broad-spectrum approach.
two hands holding mdsleep botanical blend and mdsleep +hemp

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MDsleep + hemp is Clinically Proven

 

MDsleep + hemp is clinically proven to improve sleep quality. A recent study that tested MDsleep + hemp in 620 participants showed that using lower amounts of THC combined with its proprietary blend of herbs and amino acids induced sleep better than a higher THC formula and the placebo. This is the largest study of a sleep aid to date. Sleep quality was improved in 57% of participants.  As a melatonin-free supplement, MDsleep + hemp is designed to support improved rest without the risks associated with melatonin for some users.

MDsleep Botanical Sleep Supplement

 

MDsleep Botanical Sleep Supplement features a blend of well-studied ingredients designed to encourage restful sleep without heavy sedative effects. The formula includes L-tryptophan, an amino acid that serves as a building block for crucial sleep hormones. By supporting the body’s natural production of serotonin and melatonin, L-tryptophan may help regulate the sleep-wake cycle and assist in reducing moments of wakefulness during the night.

Reasons Some Individuals May Choose Not to Use Melatonin

 

Melatonin supplements, while popular, do not suit everyone. Some people report lingering grogginess or drowsiness the morning after taking melatonin. Others find that melatonin can prompt more frequent or vivid dreams, which may disrupt their sleep quality.

 

There are cases where individuals seek help with “shutting off” racing thoughts at night. For these situations, a supplement focused on promoting relaxation and easing stress—without melatonin—may be more effective.

 

Common reasons to avoid melatonin supplements:

  • Morning sleepiness or grogginess
  • Discomfort from vivid dreams
  • Preference for alternatives for regular nightly use
  • Desire for stress reduction rather than just sleep cycle regulation
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Frequently Asked Questions

 

Which Natural Supplements Might Improve Sleep Without Using Melatonin?

Several natural options other than melatonin are used to promote sleep. Valerian root, magnesium, and chamomile are commonly taken as supplements or teas. Tart cherry juice is sometimes chosen because it may help the body produce more melatonin naturally.

 

What Are the Strongest Over-the-Counter Sleep Aids?

Some of the most potent non-prescription sleep aids include sedating antihistamines such as diphenhydramine (found in Benadryl) and doxylamine (found in Unisom). These ingredients can cause drowsiness but may lead to side effects, including dry mouth or next-day grogginess.

 

What Are Safe Sleep Support Options for Kids?

For children, non-pharmaceutical approaches are generally recommended. Options include establishing a consistent bedtime routine, using white noise, and maintaining a comfortable sleep environment. Any supplement or medication for children should only be considered under the guidance of a healthcare provider.

 

Sleep Solutions for Adults With Anxiety That Don’t Contain Melatonin

Adults dealing with anxiety and sleep difficulties may find certain herbal supplements helpful, such as passionflower or CBD (cannabidiol) products. Cognitive behavioral therapy for insomnia (CBT-I), relaxation techniques, and mindfulness practices are also frequently suggested.

 

Non-Drug Approaches to Help Toddlers Sleep Better

Non-medicine methods for toddlers focus on creating a predictable bedtime schedule, ensuring the sleep setting is dark and quiet, and limiting screen time before bed. Comfort items like a favorite blanket or soft toy can support better sleep, as can gentle soothing activities, such as reading a book together.

 

Commonly Shared Remedies for Melatonin-Free Sleep Support Online

Online discussions often mention magnesium supplements, herbal teas (like chamomile or lemon balm), and controlled-release relaxation methods such as guided meditations or sleep podcasts. People also report adjusting their evening routines to include dimming lights and avoiding caffeine to help improve sleep without melatonin.

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    Kia Michel, MD

    Kia Michel, MD

    Physician

     

    Kia Michel, MD is an urologist and staff surgeon at Cedars-Sanai Medical Center in Los Angeles.  As a founding member of Comprehensive Urology in Beverly Hills, he believes in treating all aspects of a patient’s wellbeing in order to achieve optimal health. After 25 years in private practice, Dr. Michel believes that a good night’s sleep is essential to maintaining your health, which inspired him to co-create the MDsleep community and the Sleep Doctors Blog.

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