
PhotoCredit_Syda Productions_AdobeStock
Many people seek alternatives to melatonin when looking for ways to manage sleep issues. While melatonin supplements are popular, they are not suitable for long-term use as they can create imbalance in your brain. Fortunately, these melatonin alternatives are safe and easy to use to get the rest that you need.
Top 10 Alternatives to Melatonin Supplements
Top melatonin-free options for sleep:
- MDsleep + Hemp Sleep AId
This oil, extracted from Nigella sativa, encourages relaxation and supports restful nights. Its antioxidant effects also contribute to overall well-being and may help lower stress-related issues that disrupt sleep. - MDsleep Botanical Blend
A well-known adaptogen, ashwagandha assists the body in adapting to stressful situations. It can help quiet the mind at bedtime, encourage a full night’s rest, and enhance how efficiently people spend their time in bed sleeping. - Lemon Balm
With a calming influence, lemon balm promotes peace of mind and supports the nervous system. It is a traditional option for helping manage stress and maintain a steady sleep pattern. - Valerian Root
Valerian root has long been chosen for its gentle sedative-like abilities and valerian has been studied vs melatonin. - GABA (Gamma-Aminobutyric Acid)
Supplementing with GABA may establish a sense of calm by promoting relaxation in the brain and reducing pre-bedtime tension. - CBN
CBN (cannabinol) has shown potential as a sleep aid by reducing nighttime awakenings and sleep disturbances, although it may not significantly help people fall asleep faster or improve overall sleep quality. Early studies suggest CBN can increase sleep duration and has sedative properties, but more high-quality research is needed to confirm its effectiveness for insomnia. - CBG CBG (cannabigerol) is being studies to see how much it can help to improve sleep quality and reduce stress. Preliminary studies suggest CBG may have unique pharmacological effects that could support sleep and more robust clinical trials are already underway.
- Magnesium
Known for its relaxing qualities, magnesium plays a crucial role in supporting normal nerve function and helping muscles relax, which can promote an easier transition into sleep. - Lavender
Often used in aromatherapy or oral supplements, lavender contributes to nighttime calm and can foster higher quality rest. - Cannabidiol (CBD)
CBD offers a possible option for relaxing the body and mind, helping some sleepers settle down more easily.
MDsleep + Hemp Sleep Supplement
MDsleep + Hemp Sleep Supplement features a thoughtful mix of ingredients that target various aspects of relaxation and sleep quality. The supplement includes amino acids such as L-tryptophan and glycine, both of which play roles in natural sleep regulation. L-tryptophan is involved in the body’s own neurotransmitter pathways that relate to sleep, while glycine balances calming signals in the brain.
MDsleep + Hemp Sleep Supplement Ingredients

Key Points:
- Contains a non-intoxicating form of hemp alongside well-established sleep-supporting ingredients.
- Melatonin free to avoid rebound insomnia.
- Combines amino acids, minerals, and botanical extracts for a broad-spectrum approach.
Shop MDsleep
Find sleep aids that were designed by doctors and validated by research.
MDsleep + hemp is Clinically Proven
MDsleep + hemp is clinically proven to improve sleep quality. A recent study that tested MDsleep + hemp in 620 participants showed that using lower amounts of THC combined with its proprietary blend of herbs and amino acids induced sleep better than a higher THC formula and the placebo. This is the largest study of a sleep aid to date. Sleep quality was improved in 57% of participants. As a melatonin-free supplement, MDsleep + hemp is designed to support improved rest without the risks associated with melatonin for some users.
MDsleep Botanical Sleep Supplement
MDsleep Botanical Sleep Supplement features a blend of well-studied ingredients designed to encourage restful sleep without heavy sedative effects. The formula includes L-tryptophan, an amino acid that serves as a building block for crucial sleep hormones. By supporting the body’s natural production of serotonin and melatonin, L-tryptophan may help regulate the sleep-wake cycle and assist in reducing moments of wakefulness during the night.
Reasons Some Individuals May Choose Not to Use Melatonin
Melatonin supplements, while popular, do not suit everyone. Some people report lingering grogginess or drowsiness the morning after taking melatonin. Others find that melatonin can prompt more frequent or vivid dreams, which may disrupt their sleep quality.
There are cases where individuals seek help with “shutting off” racing thoughts at night. For these situations, a supplement focused on promoting relaxation and easing stress—without melatonin—may be more effective.
Common reasons to avoid melatonin supplements:
- Morning sleepiness or grogginess
- Discomfort from vivid dreams
- Preference for alternatives for regular nightly use
- Desire for stress reduction rather than just sleep cycle regulation
Frequently Asked Questions
Which Natural Supplements Might Improve Sleep Without Using Melatonin?
Several natural options other than melatonin are used to promote sleep. Valerian root, magnesium, and chamomile are commonly taken as supplements or teas. Tart cherry juice is sometimes chosen because it may help the body produce more melatonin naturally.
What Are the Strongest Over-the-Counter Sleep Aids?
Some of the most potent non-prescription sleep aids include sedating antihistamines such as diphenhydramine (found in Benadryl) and doxylamine (found in Unisom). These ingredients can cause drowsiness but may lead to side effects, including dry mouth or next-day grogginess.
What Are Safe Sleep Support Options for Kids?
For children, non-pharmaceutical approaches are generally recommended. Options include establishing a consistent bedtime routine, using white noise, and maintaining a comfortable sleep environment. Any supplement or medication for children should only be considered under the guidance of a healthcare provider.
Sleep Solutions for Adults With Anxiety That Don’t Contain Melatonin
Adults dealing with anxiety and sleep difficulties may find certain herbal supplements helpful, such as passionflower or CBD (cannabidiol) products. Cognitive behavioral therapy for insomnia (CBT-I), relaxation techniques, and mindfulness practices are also frequently suggested.
Non-Drug Approaches to Help Toddlers Sleep Better
Non-medicine methods for toddlers focus on creating a predictable bedtime schedule, ensuring the sleep setting is dark and quiet, and limiting screen time before bed. Comfort items like a favorite blanket or soft toy can support better sleep, as can gentle soothing activities, such as reading a book together.
Commonly Shared Remedies for Melatonin-Free Sleep Support Online
Online discussions often mention magnesium supplements, herbal teas (like chamomile or lemon balm), and controlled-release relaxation methods such as guided meditations or sleep podcasts. People also report adjusting their evening routines to include dimming lights and avoiding caffeine to help improve sleep without melatonin.
CBG vs. CBN: Which Cannabinoid Is Better for Sleep?
Explore the differences between CBG and CBN, two non-psychoactive cannabinoids, and learn how each may impact energy, focus, and sleep quality. This guide discusses their unique effects, benefits, and best uses for rest and relaxation.
Read more
CBN vs. CBD: Comparing Sleep Benefits
Discover how CBN and CBD differ in their origins, effects, and potential for improving sleep. The article covers their unique properties, legal status, and which might be better suited for your sleep needs.
Read more
CBN vs. CBD vs. CBG: A Comprehensive Guide
Compare CBN, CBD, and CBG side by side to see how each cannabinoid affects sleep, pain, and anxiety. Find out which may offer the most benefits for your sleep routine.
Read more
CBG vs. CBD: Which Is Right for You?
Uncover the distinctions between CBG and CBD, including their mechanisms of action and potential wellness applications. Learn which cannabinoid may best support your sleep and overall health.
Read more
THC for Sleep: Effects and Proper Dose
Learn how THC influences sleep patterns, its potential benefits and risks, and how to determine the right dosage for restful nights. The article provides expert guidance on using THC safely for sleep support.
Read more
CBN for Sleep: How Cannabinol Can Help
Delve into the science behind CBN as a sleep aid, including its sedative properties and how it interacts with your body’s endocannabinoid system. This resource covers dosing, benefits, and considerations for using CBN to improve sleep.
Read more
Full Spectrum Hemp: Benefits and Uses
Explore the advantages of full-spectrum hemp, including its diverse cannabinoid profile and potential for promoting better sleep and relaxation. Learn how the “entourage effect” may enhance the efficacy of hemp-based sleep aids.
Read more

Kia Michel, MD
Physician
Kia Michel, MD is an urologist and staff surgeon at Cedars-Sanai Medical Center in Los Angeles. As a founding member of Comprehensive Urology in Beverly Hills, he believes in treating all aspects of a patient’s wellbeing in order to achieve optimal health. After 25 years in private practice, Dr. Michel believes that a good night’s sleep is essential to maintaining your health, which inspired him to co-create the MDsleep community and the Sleep Doctors Blog.
What Our Readers Say
“Thanks to the insightful articles, I’ve finally managed to get back to my old sleep routine. I feel more rested and energetic each day!”
“The blog’s advice on sleep hygiene has been a game-changer for me. I never realized how small changes could make such a big difference.”
“I struggled with insomnia for years, but the tips I found here have helped me sleep through the night consistently. Thank you!”
“I no longer feel like a zombie from The Walking Dead series! I finally have my life back.”
Stay Updated with Our Newsletter
Join our community of sleep enthusiasts! Subscribe to receive the latest blog posts and exclusive sleep tips straight to your inbox.
Follow Us for More Sleep Insights
Discover Better Sleep Solutions
Unlock the secrets to a restful night by exploring our expert-backed articles and join our vibrant community for personalized sleep tips.
List of References