CBN may be the less popular cousin of fellow cannabinoid CBD, but its impact on sleep quality may be greater. Many have already used CBN for sleep disturbances in the form of tinctures, CBN gummies, and pills. But did you know that new evidence shows that CBN works best for sleep when combined with other components such as GABA, L-Theanine, and botanicals such as Valerian? Today, we’ll help you understand CBN sleep effects as well as the optimal formula for sleep quality.
CBN and Its Effects on Sleep
CBN is often marketed as a sleep aid, but its exact effects and differences compared to other cannabinoids are still being researched. One study showed that Full Spectrum Hemp containing CBN, low THC, combined with GABA, L-Theanine, and Valerian significantly improved sleep quality in 57% of participants. The full-spectrum sleep formula used in the study, MDsleep + hemp, is now available to the public.
What Is CBN?
CBN, or cannabinol, is a naturally occurring compound found in the cannabis plant. It is a cannabinoid produced as THC ages and breaks down, making it more abundant in older cannabis. Unlike THC, CBN is not psychoactive at typical dosages. This means it does not cause the “high” commonly associated with cannabis use. Users report mild effects, often described as calming or sedative. CBN is found in small amounts in both hemp and marijuana. It is usually extracted and concentrated for use in supplements, including those designed to promote sleep.
How CBN Interacts With the Body
CBN interacts with the endocannabinoid system, which includes CB1 and CB2 receptors in the body. While it binds weakly to these receptors, CBN may influence sleep through effects on neurotransmitters and brain activity.
Research suggests CBN can increase both non-REM and REM sleep stages. One study indicates CBN increased total sleep time, although initial doses may sometimes suppress sleep before increasing it later. CBN may also impact underlying symptoms that affect sleep, such as anxiety or pain. These effects are still being investigated, and more controlled studies are needed to fully understand how CBN supports sleep in humans.
CBN Versus Other Cannabinoids for Sleep
CBN is commonly compared to CBD, another non-psychoactive cannabinoid. While both are used for sleep, there are key differences in their mechanisms and reported effects. CBD is widely reported to reduce anxiety and stress, which can indirectly improve sleep. In contrast, CBN is often marketed directly for sedative or sleep-promoting effects.
Clinical studies on CBN suggest that it may reduce nighttime awakenings and sleep disturbances more effectively than a placebo. However, some research shows there is no significant difference between CBN and melatonin in improving sleep quality.
CBN Works Best in Combination with Other Key Ingredients
CBN’s benefits for sleep may be more pronounced when used alongside other compounds. Studies have found that products combining CBN with melatonin or other cannabinoids can lead to better sleep outcomes.
The concept of the “entourage effect” suggests that multiple cannabis compounds working together may enhance overall effects. For sleep, this can mean combining CBN with CBD, low-dose THC, or adaptogens and botanicals.
Sleep supplements often include ingredients like L-theanine, GABA, valerian root, or magnesium to address multiple pathways that influence sleep. Combining CBN with these ingredients has been clinically shown to produce more consistent results than CBN alone or THC alone.
CBN Sleep Aid: MDsleep + hemp
MDsleep + hemp is formulated as a comprehensive sleep supplement containing full-spectrum hemp extract. This means it offers not just CBN but a range of cannabinoids and other components found in the hemp plant.
Full-spectrum products are designed to utilize all the potential benefits of hemp, rather than focusing on a single compound. This can include CBD, CBN, minor cannabinoids, terpenes, and natural flavonoids.
MDsleep + hemp aims to support restful sleep by addressing multiple causes of insomnia or sleep disruption, including stress, pain, and inflammation. Its formulation is tailored for individuals seeking a natural, plant-based approach to sleep support.
MDsleep + hemp Ingredients List
MDsleep + hemp contains a carefully selected blend of ingredients to target sleep quality:
- Full-spectrum hemp extract (includes CBD, CBN, and other cannabinoids)
- L-theanine to support relaxation
- GABA (Gamma-Aminobutyric Acid) for calming brain activity
- Valerian Root as a traditional herbal sleep a
This melatonin-free combination leverages both cannabinoid science and established sleep-promoting ingredients. The use of full-spectrum hemp extract means CBN is present alongside other beneficial plant compounds, increasing the potential for a broader effect on sleep.
How to Use CBN for Sleep
CBN, or cannabinol, is available in several forms and requires careful attention to dosage and timing to achieve sleep benefits. Proper administration can support consistent results and help minimize potential side effects.
CBN Dosage Guidelines
Current recommendations suggest that adults may start with a dose of 10–20 mg of CBN taken about 30 to 60 minutes before bed. Some studies indicate that 20 mg may reduce nighttime awakenings and improve sleep continuity, though effects may vary. It is best for new users to start at the lower end of the range and increase gradually if needed.
Individual response can differ based on body weight, metabolism, and sensitivity to cannabinoids.
Users should monitor their sleep quality and daytime alertness. If drowsiness or any adverse effects occur, adjusting the dosage or timing is appropriate. Consulting with a healthcare provider before beginning a CBN regimen is advisable, especially for those with health conditions or taking medications.
MDsleep + hemp Dosage and Timing
For products like MDsleep that combine CBN with hemp-derived CBD, take 2 softgels 60 minutes before bed.
Best Consumption Methods
CBN is available as tinctures, capsules, gummies, and sometimes combined with other sleep aids like melatonin. Tinctures are common; users place drops under the tongue and hold for up to 20 seconds before swallowing to increase absorption and promote faster effects.
Capsules offer precise dosing and are convenient for those preferring a tasteless option. Gummies are another popular choice—easy to dose, chew, and swallow, though they may take longer to act.
Some products combine CBN with CBD or melatonin for added support. The method chosen should match the user’s preference for onset speed and dosing accuracy. Experimentation within safe dose guidelines helps determine the most suitable option.
CBN Sleep Aids
CBN sleep aids are gaining popularity as a natural alternative for those seeking better rest without the grogginess often associated with traditional sleep medications. CBN, or cannabinol, is a minor cannabinoid found in hemp and cannabis plants that has shown promise for its sedative properties. Early research and user reports suggest that CBN may help reduce nighttime awakenings and promote longer, more restful sleep.
One top CBN sleep aid that is clinically proven to improve sleep quality in 57% of study participants is MDsleep + hemp sleep aid with full-spectrum hemp oil. It combines hemp oil with GABA, L-Theanine, Valerian root and a proprietary blend of botanicals to ensure the best night’s rest you can get.
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CBN Benefits for Sleep Disorders
CBN (cannabinol) is a cannabinoid that has shown potential in addressing several aspects of sleep disorders. Research and user reports point to its possible effects on insomnia, sleep quality, and relaxation.
CBN for Insomnia Relief
CBN has been studied for its sedative properties. Several clinical trials suggest that CBN may help reduce symptoms of insomnia by decreasing the time it takes to fall asleep. For people with chronic insomnia, CBN in doses as low as 20 mg nightly has resulted in fewer sleep disturbances throughout the night.
A randomized, placebo-controlled study showed that participants with insomnia taking CBN experienced a statistically significant reduction in their Insomnia Severity Index (ISI) scores. This suggests that CBN could help individuals who struggle to stay asleep or frequently wake up at night.
Some findings indicate that the effectiveness of CBN for insomnia is comparable to melatonin, a common sleep aid. While further large-scale research is needed, early results suggest that CBN is a promising option for those with sleeplessness.
CBN for Improving Sleep Quality
CBN may contribute to overall improvements in sleep quality beyond promoting sleep onset. In preliminary studies, people taking CBN reported better overall sleep, including longer sleep duration and fewer nighttime awakenings.
One notable outcome is CBN’s potential to help users spend more time in restorative deep sleep. This stage of sleep is essential for physical and mental recovery. Improvements in deep sleep can result in better mood, alertness, and cognitive function the following day.
Available evidence also suggests that CBN’s benefits for sleep quality are similar to, but not greater than, those provided by melatonin. Side effects reported in studies have been minimal, indicating good tolerability.
CBN for Promoting Relaxation
CBN is believed to have calming effects that support the body’s ability to relax before bedtime. Animal studies and anecdotal reports suggest that it may ease the transition from wakefulness to sleep by reducing mental and physical tension.
This relaxation may be linked to how CBN interacts with the body’s endocannabinoid system. By influencing certain receptors, CBN can help regulate nervous system activity and lower arousal levels.
Unlike some pharmaceutical sleep aids, CBN does not usually cause next-day grogginess at typical dosages. This has made it an option for those seeking to wind down without lingering morning effects.
Scientific Research on CBN for Sleep
Several studies have examined the effects of cannabinol (CBN) on sleep, investigating its potential benefits and limitations. Results vary depending on study design, dosage, and populations studied, but some patterns are emerging.
MDsleep + hemp Sleep Study
The MDsleep + hemp Sleep Study reviewed the impact of CBN-rich hemp extracts on adult sleep patterns. The study measured sleep quality, ease of falling asleep, and number of nighttime awakenings before and after using the product.
Participants reported a decrease in how often they woke during the night after regular use of CBN. Improvements included longer durations of non-REM sleep bouts, which are important indicators of better sleep stability. No major adverse effects were reported, suggesting CBN is generally well tolerated in healthy adults.
The research also followed participants for multiple weeks, observing that initial improvements in sleep stability with CBN were sometimes reduced over time due to tolerance. This highlights the importance of monitoring both short-term effects and possible adaptations to CBN’s influence on sleep.
Key Studies and Findings
Recent double-blind, placebo-controlled trials have tested various dosages of CBN on sleep disturbances. A study using 20 mg CBN nightly found participants had fewer nighttime awakenings and reported less overall sleep disturbance compared to placebo. Another trial with doses ranging from 30 to 300 mg showed significant reductions on the Insomnia Severity Index (ISI).
Evidence suggests CBN can assist with sleep initiation and maintenance in some individuals. However, the quality of scientific data is limited by small sample sizes and variations in methodology. Some studies noted tolerance may develop with daily use, making long-term benefits less clear without additional research.
Key outcomes from selected studies:
| Study | CBN Dose | Major Finding |
| Randomized trial | 20 mg | Fewer night awakenings, improved sleep disturbance |
| Open-label | 30-300 mg | ISI decreased by 5.1 points vs placebo |
CBN Sleep Products
CBN is increasingly included in a range of products marketed for sleep support. Product options and quality standards vary, making careful selection important for consumers seeking effective and safe solutions.
MDsleep +hemp (Melatonin Free)
MDsleep +hemp (Melatonin Free) is formulated for individuals sensitive to melatonin or those who prefer to avoid it. This product blends CBN, hemp extract, and supporting botanicals to target sleep disturbances without hormones.
Key features include:
- Melatonin-free formula: Suitable for those with adverse reactions to melatonin.
- Full spectrum hemp extract: Provides a wide range of cannabinoids, including CBN, which is believed to help with sleep and relaxation.
- Botanical support: Ingredients such as valerian root and chamomile may be added to support sleep onset.
The absence of melatonin sets MDsleep +hemp apart from many other sleep products.
Choosing Quality CBN Supplements
Selecting a reputable CBN sleep product involves consideration of several factors. Not all CBN supplements are created equal, and quality impacts both safety and effectiveness.
A few guidelines to follow:
- Check for third-party testing: Reliable brands provide lab results verifying CBN content, absence of contaminants (e.g., heavy metals or pesticides), and THC levels below legal limits.
- Full spectrum vs. isolate: Full spectrum products contain a variety of cannabinoids and terpenes that may enhance CBN’s effects through the entourage effect, while isolates include only CBN.
- Clear labeling: Look for precise milligram amounts of CBN per serving and transparent ingredient lists.
- Origin of hemp: U.S.-grown hemp is preferred for quality assurance due to stricter regulations.
Mislabeling and inconsistent potency can be a concern with some products. Consumers should research company reputation and read customer reviews to further gauge reliability.
Potential Side Effects and Safety
Research on CBN’s safety for sleep is limited, but early findings point to some mild and manageable concerns. Anyone considering CBN should be aware of possible negative effects and the potential for drug interactions.
Possible Adverse Reactions
Most evidence indicates that CBN is generally well-tolerated when taken in typical amounts. Some users have reported mild side effects, such as:
- Fatigue or drowsiness
- Dry mouth
- Dizziness
Rarely, users might notice an increased heart rate or feel slightly lightheaded, particularly at higher doses. There is limited evidence about the long-term safety of CBN, and no serious side effects have been consistently documented. Because research is ongoing, individuals should monitor for unexpected symptoms and use caution when trying new doses.
Drug Interactions
CBN can interact with other substances, especially medications that affect the central nervous system. Mixing CBN with drugs that cause sedation, such as sleep aids or anti-anxiety medications, may increase the overall sedative effect, leading to increased drowsiness or impairment.
It is possible that CBN could interact with medications that are broken down by the liver, such as some antidepressants or blood thinners. Anyone taking prescription drugs should consult their healthcare provider before adding CBN. Those with concerns about mental health or heart rate changes should be especially cautious and seek medical advice before using CBN products.
Frequently Asked Questions
CBN has gained interest for its role in supporting restful sleep and its interactions with cannabinoids like CBD. Understanding its side effects, usage forms, and sourcing can help consumers make informed decisions.
What are the potential side effects of taking CBN for sleep?
The most commonly reported side effects of CBN include mild drowsiness, dry mouth, and dizziness. Some individuals have experienced next-day grogginess, but these effects are generally considered mild compared to other sleep aids. Limited research means long-term safety is not well understood. Individuals should consult with a healthcare provider before starting CBN, especially if taking other sedatives or prescription medications.
How do CBN gummies differ from other CBN products in promoting sleep?
CBN gummies deliver a consistent, pre-measured dosage and are easy to consume. They often combine CBN with other sleep-supporting ingredients like melatonin or CBD. Other forms, such as tinctures or capsules, may absorb more quickly or allow for more precise titration of dosage. Gummies may take slightly longer to take effect due to digestion.
What are the best-rated CBN products specifically designed for improving sleep?
Highly rated CBN sleep products generally contain third-party lab test results and clear labeling of CBN content per serving. Products that combine CBN with CBD or melatonin often receive positive reviews for effectiveness. Top-rated brands are commonly mentioned on reputable health sites and have transparent manufacturing processes. It’s important to read reviews from verified buyers and consult independent product analysis sites.
Can CBN also be used to manage anxiety, and how does that relate to its sleep-inducing properties?
Some users report that CBN helps lower anxiety, potentially due to its relaxing and mild sedative effects. Research is limited and less robust than for CBD, but anecdotal feedback suggests some anxiety relief. Lower anxiety levels before bedtime may contribute to falling asleep more easily, but CBN’s direct impact on anxiety has not been as well studied as its sleep-related effects.
Where can consumers find reputable sources to purchase CBN products for sleep?
Reputable CBN products are available from licensed dispensaries, established online retailers, and brands that provide independent lab testing results. It is best to purchase from sources that clearly state product ingredients and manufacturing standards. Look for products with transparent labeling and verifiable customer reviews. Avoid unregulated or unknown sellers, especially those without third-party testing.
How does the combination of CBD and CBN affect sleep quality compared to using CBN alone?
Some studies and user experiences indicate that combining CBD and CBN may enhance relaxation and improve sleep quality over CBN alone. The two cannabinoids may work together through different pathways in the endocannabinoid system. Products with both cannabinoids are commonly formulated for night-time use and may be ideal for those with difficulty both falling and staying asleep. Research on optimal ratios and efficacy is ongoing.
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Kia Michel, MD
Physician
Kia Michel, MD is an urologist and staff surgeon at Cedars-Sanai Medical Center in Los Angeles. As a founding member of Comprehensive Urology in Beverly Hills, he believes in treating all aspects of a patient’s wellbeing in order to achieve optimal health. After 25 years in private practice, Dr. Michel believes that a good night’s sleep is essential to maintaining your health, which inspired him to co-create the MDsleep community and the Sleep Doctors Blog.
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List of References
- AASM Sleep Prioritization Survey: This survey by the American Academy of Sleep Medicine examines the use of melatonin among the public. It reveals trends and insights into how melatonin influences sleep patterns. For more information, visit AASM Sleep Prioritization Survey, Melatonin Use.
- Melatonin Overview: The A.D.A.M. Medical Encyclopedia provides a detailed entry on melatonin, discussing its role as a natural hormone and its applications in treating sleep disorders. More details can be found at Melatonin – MedlinePlus.