
Sleep aids can help you recover from sleep debt, but which ones actually work? Both over-the-counter sleep aids and prescriptions are commonly used by millions of Americans for occasional sleeplessness and frequent sleep disruptions. We’ll guide you through the science on all the varieties of herbs, vitamins, cannabis, and combination sleep supplements that are recommended by sleep doctors.
Types of Sleep Aids Available
A variety of sleep aids exist, ranging from nonmedicated options to both over-the-counter and prescription medications. These aids address everything from occasional sleeplessness to more persistent sleep challenges.
Types of Sleep Aids Include:
- Over The Counter Sleep Aids
- Prescription Sleep Aids
- Herbs for Sleep
- Vitamins for Sleep
- Cannabis for Sleep
Medicated solutions can present potential side effects, risks, and the possibility of dependency, making it crucial for individuals to consult a healthcare professional about their choices. This is why a team of physicians at MDBio Wellness crafted a clinically proven over-the-counter sleep aid called MDsleep.
There are two versions of MDsleep:
MDsleep +hemp is a melatonin-free, non-intoxicating, relaxing nighttime supplement clinically proven to promote and prolong restful sleep by calming the mind and the body.
Getting enough sleep is essential. Sleep deprivation not only leads to fatigue but may also trigger several complications, such as:
- Mood disturbances
- Impaired focus and slower reaction times
- Increased susceptibility to conditions like hypertension, diabetes, heart disease, and dementia
Finding the appropriate sleep aid is essential for better overall health and well-being.
When Sleep Aids May Be Appropriate
Determining the need for sleep aids depends mainly on the specific sleep difficulties experienced. Personal beliefs also play a role, as some individuals may choose to avoid medication altogether.
Considerations include:
- Occasional insomnia: Difficulty falling or staying asleep may warrant temporary use of over-the-counter options.
- Sleep hygiene practices: Adopting healthy sleep habits can often improve sleep quality.
- Natural remedies: Solutions like herbal teas or melatonin may provide relief.
- Professional guidance: Consulting a doctor about potential side effects and risks associated with sleep aids is crucial.
- Chronic sleep issues: Persistent struggles may benefit from cognitive behavior therapy or prescription medications tailored to address specific symptoms.
Individuals can make informed decisions about their sleep health by understanding these factors.
Non-Medicated Ways to Improve Sleep
Healthy Sleeping Practices
Establishing a set of practices to enhance sleep quality is known as sleep hygiene. Consistency is key to achieving restful nights.
The following habits can help foster better sleep:
- Set a Sleep Schedule: Choose a specific bedtime that can be maintained each night, as this lays the groundwork for a refreshing morning.
- Limit Caffeine Intake: Avoid consuming caffeine after noon to prevent interference with sleep.
- Time Your Workouts: Refrain from exercising within an hour before sleep, as an elevated body temperature may hinder the ability to rest.
- Cool Sleeping Environment: Keep the bedroom temperature below 70 degrees to promote a comfortable sleeping atmosphere.
- Minimize Noise Distractions: Sleep should not be interrupted by loud noises from electronics like televisions or radios.
- Screen Time Rules: Avoid screen usage for at least an hour before bed, since blue light can disrupt melatonin production and signal wakefulness to the brain.
- Remove Clocks: Position clocks out of view from the bed to alleviate the urge to check the time during the night.
- Alcohol Avoidance: Steer clear of alcoholic beverages for at least three hours before bedtime, as they can lead to restless sleep and frequent awakenings.
In the event of difficulty falling asleep or nighttime awakenings, several strategies may help:
- Listening Aid: Use a sleep or meditation app to promote relaxation.
- Visualization: Focus on a pleasant dream to distract from intrusive thoughts.
- Thought Management: Ask if current thoughts require immediate attention. If not, remind oneself that it is time to sleep.
- Reading for Rest: If awake for over 30 minutes, get out of bed and engage with a dull book; after 15 minutes, attempt to sleep again.
Herbal and Natural Remedies
In addition to good sleep practices, various natural remedies can assist with occasional sleeplessness. One well-known option is melatonin, a hormone that regulates sleep-wake cycles. Other potential aids include herbal teas and supplements that may promote relaxation.
Behavioral Techniques for Sleep
Cognitive behavior therapy (CBT) can benefit those struggling with sleep. A trained therapist assists individuals in identifying stressors that contribute to insomnia. Over several sessions, clients learn techniques to manage racing thoughts and achieve a calm state conducive to sleep.
Through consistent practice, these strategies can improve the ability to fall asleep and the quality of rest throughout the night.
Over-the-Counter Sleep Aids
Individuals may need sleep aids due to various factors like stress, traveling, or heightened excitement. While using non-prescription sleep aids can provide relief on occasion, it is vital to understand the associated risks and side effects. Such aids should be considered for short-term use, and consultation with a healthcare professional is recommended.
Sleep Aids with Antihistamines: Diphenhydramine and Doxylamine Succinate
Diphenhydramine is a sedating antihistamine commonly found in various over-the-counter sleep medications and allergy treatments. Similarly, doxylamine succinate is another sedating antihistamine widely used in sleep aids. Both compounds work by lowering histamine levels in the brain, facilitating the body’s natural readiness for sleep.
Usage: These medications may be helpful after particularly stressful days or during travel disruptions like jet lag.
Side Effects and Risks: Regular use of diphenhydramine or doxylamine succinate is discouraged due to potential side effects, including:
- Increased risk of dementia in older adults
- Anticholinergic effects can influence the nervous system; research indicates increased dementia risk can persist for up to 20 years post-exposure
- Common adverse effects such as:
- Daytime grogginess
- Dry mouth
- Constipation
- Difficulty urinating
- Blurred vision
Precautions: These aids are unsuitable for individuals who are:
- Aged 65 and older
- Pregnant or breastfeeding
Additionally, they should be avoided by those with conditions like:
- Closed-angle glaucoma
- Peptic ulcers
- Urinary retention
Caution is advised, particularly to:
- Avoid alcohol when taking sleep medications to prevent increased sedative effects.
- Refrain from driving or engaging in alertness-demanding activities until the effects have dissipated.
- Discuss long-term use with a healthcare provider if using diphenhydramine for other purposes, such as allergies.
Melatonin
Melatonin is a hormone produced by the body that regulates the sleep-wake cycle. Unlike antihistamines, melatonin supplements do not induce sleep directly; instead, they assist in raising melatonin levels to encourage sleep.
Usage: Melatonin can be particularly effective for intermittent insomnia and counteracting jet lag. It’s recommended to take it roughly an hour before bedtime for optimal effects. It is available in short-acting and long-acting formulations, with long-acting versions potentially reducing night awakenings.
Side Effects and Risks: Users may experience mild side effects such as nausea, headaches, or daytime drowsiness. Some studies have suggested a potential reduction in sperm counts in male test subjects, prompting those undergoing fertility evaluations to consult their healthcare provider before use.
Contraindications: Individuals should avoid melatonin if they:
- Are you pregnant or breastfeeding
- Have autoimmune disorders, seizure disorders, or depression
Valerian
Valerian is a herb that has historically been utilized as a natural remedy for sleep issues.
Usage: The effectiveness of valerian remains unclear, as there is no definitive evidence supporting its benefits for sleep.
Side Effects: The side effects associated with valerian are typically mild, including symptoms like headaches or feelings of weakness.
Additional Nonprescription Sleep Aids
Numerous supplements and vitamins are believed to aid sleep, but individuals must consult their healthcare provider before trying any new remedy. Due to the lack of regulation for supplements and herbal products in the U.S., selecting products from reputable manufacturers is essential to ensure safety and efficacy.
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Prescription Sleep Aids
When sleep disturbances persist despite implementing good sleep practices and other remedies, it may be worthwhile to consult a healthcare professional regarding prescription sleep medications. These medications vary in duration of use; some are formulated for occasional relief, while others are designed for individuals with chronic insomnia or related conditions that disrupt sleep consistently.
It is essential to recognize that these medications can carry risks and potential side effects, including the possibility of dependence.
Therefore, thoroughly discussing with a healthcare provider is essential before initiating treatment. Patients should promptly inform their doctor of any adverse effects they experience.
Many sleep medications are available under both generic and brand names. Below is a list of some commonly prescribed sleep aids, along with their effects and potential risks associated with their use:
Generic Name |
Function |
Risk of Dependence |
Daridorecant |
Supports both falling and staying asleep |
Yes |
Doxepin |
Primarily helps with staying asleep |
No |
Eszopiclone |
Aids in falling and staying asleep |
Yes |
Lemborexant |
Assists with falling and staying asleep |
Yes |
Ramelteon |
Focuses on helping to fall asleep |
No |
Suvorexant |
Aids in both falling and staying asleep |
Yes |
Temazepam |
Supports both falling and staying asleep |
Yes |
Triazolam |
Helps with falling asleep |
Yes |
Zaleplon |
Specifically aids in falling asleep |
Yes |
Zolpidem |
Supports both falling and staying asleep |
Yes |
Side Effects of Prescription Sleep Aids
Individuals must communicate any side effects experienced while taking sleep aids to their healthcare provider. Common side effects associated with these medications include:
- Dizziness or lightheadedness, which can increase the risk of falls
- Gastrointestinal disturbances, such as nausea or diarrhea
- Extended drowsiness beyond intended use
- Severe allergic reactions
- Disturbances in sleep-related behavior, which may include engaging in activities like driving or eating while not fully awake
- Mental health side effects, including hallucinations, heightened agitation, memory issues, or suicidal ideation
- Challenges with daytime memory and focus
Awareness of these potential side effects allows patients to communicate openly with their healthcare provider to ensure safe usage.
Antidepressant Medications with Sedative Properties
Certain medications prescribed for depression may also produce sedative effects when taken at lower doses, aiding individuals who struggle with insomnia as a result of depression or anxiety. While the FDA does not explicitly approve these medications for insomnia treatment, they might be utilized as an alternative.
Some examples of these medications include:
- Amitriptyline
- Mirtazapine
- Trazodone
The side effects associated with these antidepressants can resemble those of traditional sleep aids. These may include:
- Dizziness
- Headaches
- Lengthened drowsiness
- Dry mouth sensations
- Occasional lightheadedness
- Nausea
- Changes in heart rhythm
- Weight fluctuations
- Memory and performance issues
- Gastrointestinal disturbances, such as constipation or diarrhea
- Thoughts of self-harm
Awareness of these risks supports informed decision-making about treatment options.
Considerations for Safe Use of Prescription Sleep Aids
To promote both personal safety and the well-being of others, individuals should follow specific guidelines when using prescription sleep aids:
- Discuss with healthcare providers and review medication guides to understand possible side effects and associated risks fully.
- Adhere strictly to prescribed dosages and timing. For instance, taking sleep medication during the day can cause significant drowsiness during daily activities.
- Only take sleep medications when a whole night’s rest is available. These prescriptions typically facilitate seven to eight uninterrupted hours of sleep.
- Allow for a period of adjustment when beginning a new medication. Avoid starting any sleep medication immediately before significant events, as side effects can vary.
- Refrain from combining sleep aids with alcohol or opioids. This combination can amplify sedation effects, leading to dizziness, confusion, and even severe respiratory issues.
- Recognize that most prescription sleep medications are not intended for long-term use. Regular evaluations with a healthcare provider can help assess the medication’s effectiveness and appropriateness.
- If medication discontinuation is being considered, discuss it with a healthcare professional, as some medicines may require a gradual dose reduction.
As individuals age, their physiological responses to medications may change; therefore, maintaining an ongoing dialogue with healthcare providers about all medicines taken is essential for safe and effective treatment. Good sleep hygiene is a critical component of overall health, and healthcare providers can assist in developing appropriate strategies tailored to individual needs.
Frequently Asked Questions
What are the most effective over-the-counter sleep aids available?
Many individuals find succor in over-the-counter sleep aids that typically contain antihistamines, such as diphenhydramine and doxylamine. These can assist with occasional sleeplessness. It is important to note that reliance on these could diminish effects over time.
What are some powerful natural remedies for improving sleep?
Natural remedies for better sleep can include supplements like melatonin, magnesium, and valerian root. Additionally, maintaining good sleep hygiene by establishing a consistent sleep schedule, reducing screen time before bed, and creating a relaxing bedtime routine can significantly enhance sleep quality.
What sleep aid options are recommended for individuals dealing with anxiety?
For those experiencing anxiety-related sleep disturbances, cognitive behavioral therapy for insomnia (CBT-I) is often recommended. Certain medications, like selective serotonin reuptake inhibitors (SSRIs), may also be prescribed to help alleviate both anxiety and sleep issues.
What are the names of strong prescription sleeping medications?
Prescription medications that are commonly considered potent sleep aids include zolpidem (Ambien), eszopiclone (Lunesta), and temazepam (Restoril). These medications tend to have more significant sedative effects compared to over-the-counter options.
Are there any risks associated with commonly used sleeping pills?
Using sleeping pills can carry several risks, such as dependence, tolerance, and withdrawal symptoms. Additionally, these medications may lead to side effects like dizziness, grogginess, and impaired coordination, making it crucial to use them judiciously.
How can I identify non-addictive sleeping pills?
To identify non-addictive sleep aids, individuals can look for options considered safe for long-term use, such as certain antihistamines or melatonin. Consulting a healthcare professional for guidance on selecting the right sleep aid is advisable, particularly for those concerned about addiction.

Kia Michel, MD
Physician
Kia Michel, MD is an urologist and staff surgeon at Cedars-Sanai Medical Center in Los Angeles. As a founding member of Comprehensive Urology in Beverly Hills, he believes in treating all aspects of a patient’s wellbeing in order to achieve optimal health. After 25 years in private practice, Dr. Michel believes that a good night’s sleep is essential to maintaining your health, which inspired him to co-create the MDsleep community and the Sleep Doctors Blog.
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List of References
- AASM Sleep Prioritization Survey: This survey by the American Academy of Sleep Medicine examines the use of melatonin among the public. It reveals trends and insights into how melatonin influences sleep patterns. For more information, visit AASM Sleep Prioritization Survey, Melatonin Use.
- Melatonin Overview: The A.D.A.M. Medical Encyclopedia provides a detailed entry on melatonin, discussing its role as a natural hormone and its applications in treating sleep disorders. More details can be found at Melatonin – MedlinePlus.
- Cannabinoids and Sleep: A study by Kaul, Zee, and Sahni reviews the effects of cannabinoids on sleep and their potential therapeutic roles in managing sleep disorders. This research can be accessed through Neurotherapeutics.
- Insomnia and Substance Use Disorders: Arnedt discusses insomnia in individuals with substance use disorders, highlighting how these conditions interact. This information is available in UpToDate at Insomnia in Patients with a Substance Use Disorder.
- Clinical Trials of Cannabinoids: Kuhathasan et al. provide a critical review focusing on clinical trials that investigate cannabinoids for sleep improvement. For full access, check Experimental and Clinical Psychopharmacology.
- Cannabis and Sleep Literature Review: Babson, Sottile, and Morabito explore the relationship between cannabis, cannabinoids, and sleep through a literature review. Find their findings in Current Psychiatry Reports.
- Cannabidiol (CBD) Information: This entry from the A.D.A.M. Medical Encyclopedia details CBD, a compound from cannabis known for its potential benefits in sleep enhancement. More information is at Cannabidiol (CBD) – MedlinePlus.
- Magnesium for Insomnia: A systematic review and meta-analysis by Mah and Pitre investigates the impact of oral magnesium supplementation on insomnia in older adults. Read about it in BMC Complementary Medicine and Therapies.
- Dietary Magnesium: The A.D.A.M. Medical Encyclopedia discusses the role of magnesium in diet, emphasizing its importance for sleep and overall health. Further details are provided at Magnesium in Diet – MedlinePlus.
- Safe Natural Sleep Aids: Rao et al. investigate various natural sleep aids available in the market, searching for effective options for sleep improvement. The study is accessible at Journal of the American College of Nutrition.
- Theanine’s Effect on Sleep: Baba and colleagues explore how theanine influences sleep quality, particularly in young women affected by caffeine-induced wakefulness. More can be found in Food & Function.
- Theanine Complex and Sleep Quality: Research by Dasdelen et al. presents findings on a novel theanine complex that improves sleep quality. It is published in Frontiers in Nutrition.
- Glycine and Sleep: Kawai et al. study the effects of glycine on sleep and the brain, focusing on how it may assist with sleep disorders. Details can be found at Neuropsychopharmacology.
- Valerian Root Information: Shane-McWhorter provides insights into valerian as a natural sleep aid, detailing its usage and effects in the Merck Manual. Visit Valerian – Merck Manual Professional Version.